The effect of sleep apnea, APOE genotype and its interaction on Lead Investigator: Wenjun Zhou Institution : Zhongshan Hospital, Fudan University E-Mail : zhouwenjunhx@163.com Proposal ID : 861 Proposal Description: We intend to examine the effect of sleep apnea, APOE genotype and its interaction on cognition,psychiatric symptoms and neuroimaging in CN, aMCI and AD. We intend to examine the effect of sleep apnea, APOE genotype and its interaction on cognition and neuroimaging in CN, aMCI and AD subjects. We will be focusing on these variables, including comprehensive demographics, neuropsychological tests, MRI caculated volumes, subject health history, weight and height, GDS and APOE genotype.